Recommended target levels20,21
Serum ferritin
500 – 1000 µg/l20
Standards for the Clinical Care of Children and Adults with Thalassaemia in the UK recommend serum ferritin levels should be measured 1 - 3 monthly.20
Cardiac MRI T2*
20 ms or higher21
The American Heart Association (AHA) recommends cardiac MRI T2* assessments to be completed annually or every 6 months for those with T2* <10ms.21
Liver LIC
3 mg/g dry weight20
Standards for the Clinical Care of Children and Adults with Thalassaemia in the UK recommend LIC assessments to be guided by the rate of change in LIC: 20
3-7 mg/g dw: 1-2 yearly
>7 mg/g dw: yearly
<3 mg/g dw: 6-12 monthly
LIC has long been considered as the “gold” standard for assessing total body iron load. It has, for a long time, been based on the measurement of the iron content of a liver biopsy sample. This approach has now largely been replaced by the noninvasive method of magnetic resonance imaging (MRI).22
By showing iron distribution between liver and spleen, MRI specific sequences provide valuable clues to the clinician onto the pathophysiology of iron overload.22
For HCP: In case you want to report an adverse drug reaction you become aware of, please report it to your Health Authority according to the requirements set by the pharmacovigilance legislation.